Orthomolecular treatment, as conceptualized by double-Nobel laureate Linus Pauling, aims to restore the optimum environment of the body by correcting imbalances (excesses or deficiencies) based on an individual’s biochemistry, using substances natural to the body  such as vitamins, minerals, amino acids, trace elements and fatty acids. The term “orthomolecular” (therapeutic nutrition) was first used by Linus Pauling in a paper he wrote in the journal Science in 1968.

The key idea in orthomolecular treatment is that genetic factors are limited in their affect on the physical characteristics of individuals, and their biochemical milieu. In larger measure, it is the Epi-genetic (above genetics) factors that have the greatest impact on healing or illness. Body chemical pathways of the body have significant genetic variability (as impacted by all ‘environmental’ factors). Degenerative diseases such as atherosclerosis, cancer, schizophrenia or depression are associated with specific 'Epi-genetic' biochemical and psychological abnormalities (toxicities, nutrient deficiencies and excesses) which are the primary causal or contributing factors of all illness and disease.