Piper longum has demonstrated remarkable effects against numerous diseases and conditions, including cancer, inflammation, depression, diabetes, obesity, and hepatotoxicity. The plant markedly improves microbial infections, cardiac disease, and protects against the effects of radiation.

Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar, and help prevent heart disease.

Buxus Sinica or Fisetin and a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a coloring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers. Its chemical formula was first described by Austrian chemist Josef Herzig in 1891. The biological activity of fisetin has been studied in many laboratory assays; like other polyphenols it has many activities. Function 1.expelling wind and dampness, qi and blood. Indications Rheumatoid arthritis, diarrhea, stomach pain, hernia pain, abdominal distention, pain, bruises, swelling, sores, carbuncles. Fisetin can be used to cure rheumatism, dysentery, gastrological, hernia, abdominal distension, toothache, traumatic injuries, and skin ulcer in clinical. Fisetin can be used as anti-inflammatory and antiproliferative Application Fisetin can be used to cure rheumatism, dysentery, gastrological, hernia, abdominal distension, toothache, traumatic injuries, and skin ulcer in clinical. Fisetin can be used as anti-inflammatory and antiproliferative Fisetin can indicate rheumatoid arthritis, diarrhea, stomach pain, hernia pain, abdominal distention, pain, bruises, swelling, sores, carbuncles. Natural fisetin dispel wind and dehumidify. There is also much suggestive evidence the Fisetin may help clear Senescent Cells.

Niacin (Nicatinamide) is a mitochondrial aide to energy production. Niacin (also known as “vitamin B3” or “vitamin PP”) is the generic descriptor for two vitamers, nicotinic acid (pyridine-3-carboxylic acid) and nicotinamide (nicotinic acid amide), that give rise to the biologically active coenzymes, nicotinamide adenine dinucleotide (NAD) and its phosphate analog, the nicotinamide adenine dinucleotide phosphate (NADP. The two coenzymes take part in redox reactions crucial for energy production: in particular, the pyridinic ring can accept and donate a hydride ion (:H−, the equivalent of a proton and two electrons), thus acting as an electron carrier. Nonetheless, NAD and NADP play different metabolic roles in the cytosol: the NADH/NAD+ ratio is small (about 8 × 10−4), thus favoring oxidative catabolism, whereas the NADPH/NADP+ ratio is higher (about 75), thus providing a strongly reducing environment for biosynthetic reactions.

Niacinamide (Vitamin B3 )is found in blood in the form of niacinamide (also known as nicotinamide). It can enter the blood–brain barrier (BBB) easily, is nonaddictive, and is devoid of the flush effect of niacin form of vitamin B3. Tryptophan can be converted to either niacin or serotonin, and exogenous niacinamide may signal via feedback inhibition to decrease the activity of tryptophan pyrrolase (the enzyme that converts tryptophan to niacin). This allowed more tryptophan to be converted to 5-HTP and then to serotonin.